The Abicana Store
The sexual booster herb epidemium, presentation of male sex products based on epidemium and other ingredients
Welcome to this site where you can find information about the aphrodisiac and medical herb Epidemium. Then you can find an exhibition of sex drugs for men to be taken by mouth and that give an effect on the virility throughout the whole day and night, of which several contain epidemium. At the bottom of this page there is some information about the encyme PFE5 and the signal substance cGMP which play a role in many physiological procese, including the sexual responce.
To find more articles with information about sex, health and fitness, please click here
About horny goat weed, Epidemium, and its medical and sexual use
Botanical Names differ according to what exact species of epidemium that is used: 1. Epimedium koreanum Nakai; 2. Epimedium sagittatum (Sieb. et Zucc.) Maxim.; 3. Epimedium brevicornum Maxim.; 4. Epimedium pubescens Maxim. Barrenwort, Herba Epimedii, Horny Goat Weed, Japanese Epimedium, Xian Ling Pi, Yin Yang Huo. Epimedium acuminatum; Epimedium grandiflorum; Epimedium wushanese, and other Epimedium species.
Natively one finds Epidemium variants mainly in China, in some other Aian areas and to some extent in the Mediterranean area. The green parts of the plants last for one season, for some species a year, and for just a few species several years. The flowers are symmetrical with four of each part in the flower.
The flowers have four small outer greenish sepals which often fall off when the flower opens. Inside these are four other brigntly colored sepals that look like petals. More inside are the true, often small, but complicated shaped petals, and with a nectar-producing spur. There are four stamens. Also the style is four-fold with four stigmas and four-fold ovary.
Varying according to species there are one or several thightly assambled stems. Some species have only one leaf at the base of the stem, while others have several of them along the stem. The leaves are typically compunded with three leaflets with spiny margines.
Epidemium belongs to the family Berberidaceae. Source of warliest record is Haiyao Bencao.
Leaves of Epidemium grandiflorum(The picture is from wikipedia.org and is therefore free to reuse)
How the plant is prepared
Part Used & Method for Pharmaceutical Preparations : The aerial part of the herb is gathered in spring and autumn, dried in the sun and cut into pieces.
The medical effects of epidemium
Hornry Goat Weed increases energy, libido, sperm production, stimulates the sensory nerves and increases sexual desire. In addition, research has shown that Horny Goat Weed has anti-fatigue effects and helps prevents adrenal exhaustion. The herb has also been traditionally used for liver and kidney tonification.
Horny Goat Weed`s aphrodisiac effects has been verified in both animal and human research. Mice treated with a Horny Goat Weed preparation produced "apparent effects on the improvement of sexuality." It was also shown to improve sperm producing capability. Since Horny Goat Weed has been traditionally used for kidney disease, it's interesting that research has demonstrated a sexual potentiation effect and improved quality of life in patients with chronic renal failure who were given Horny Goat Weed.
Animal studies using epimedium have shown a reduction in bone breakdown, an increase in muscle mass, and a loss of body fat-each of which may be linked to the observed return of abnormal cortisol levels back to normal values (and rhythm). In a series of studies conducted in humans and animals by Chinese researchers, immune-system function was directly suppressed and bone loss was accelerated, by using high-dose synthetic cortisol (glucocorticoid drugs). Subsequent administration of epimedium extract reduced blood levels of cortisol and improved immune immune-system function (in the humans) and slowed bone loss and strengthened bones (in the animals).
Epidemium as further been used for treatment of impotence, involuntary ejaculation, weak back and knees, arthralgia, mental and physical fatigue, memory loss, hypertension, coronary heart disease, bronchitis, chronic hepatitis, polio, chronic leukopenia, viral myocarditis.
Research has shown that Horny Goat Weed significantly increases testosterone in mice. This certainly appears to be one of the herb's mechanism of action, although Horny Goat Weed may have more than one. For example, it has been established that sexual arousal is linked to the activity of cholinergic neurotransmitters. However, an enzyme called acetylcholinesterase (AChE) inactivates cholinergic neurotransmitters within 1/500 of a second. As it turns out, research shows that Horny Goat Weed is capable of inhibiting AChE. Such an inhibition may support higher levels of the key cholinergic neurotransmitters associated with sexual arousal. It also seems to restore production of thyroid hormones when these are in defiency.
Horny Goat Weed is a traditional botanical medicine used in China and Japan. Although this herb (which also goes by the names Yin Yang Huo, Inyokaku, and Herba Epimedii) has a history of traditional use for disorders of the kidneys, joints, liver, back and knees, its principle use is as an aphrodisiac.
The mechanism of the sexual action of epidemium
The active ingredient in Epimedium is icariin, which can be found in standardized extracts from 5% up to 60% consentration.
Icariin seems to increase the leverl of nitrix oxide in tissues releasing this compound, and thus it increases the elevel of this compound in the penile and genital tissues of men. Nitric oxide relaxes smooth muscles in the blood vessels leading blood to the penis and in the network of blood vessels within the penis. This causes the penis to be filled with blood and engorge.
There has been done scientific experments where icariin has been injected into the penile tissues in rats, and these experiments have demonstrated the relaxation of smooth muscles within the penis and an increased penile blood pressure.
Icariin inhibits the activity of PFE5. PFE5 is an enzyne that breaks down the compound cGMF. Thus the action of icariin increases the amount of cGMF in the penile tissue and other tissues. cGNF is a tool used in the production of nitric oxide. Therefore Icariin wil increase the amount of nitric oxide in the penile tissues.
Natural medicals for men to improve sexual
life or to help for health problems
Here are exhibited some natural products for men to optimize sexual functions and to maximize sexual satisfaction. There are also links to sources of natural drugs for other purposes and for sex enhancer products for women. Pleace click on the banners to learn more or to buy.
Natural drugs to give strong sexual physiology
Pills to improve the male sexual processes, including inetsifying the orgasms and making effective production of semen
- These pills are formulated to improve and
increase the functions in the intimate zones of men. They will give the semen
better consistance, make you produce more semen and make better fertility. The
actions of pumping out and emptying your stores of semen during orgasm and
ejaculation will be stronger. You will feel good more intensely, erect stronger
and feel higher aroused. Please look at these two good products for these purposes and chose that which fits best your needs.
ProSolution Plus - Pills to make the penis effective and avoid premature ajaculation
- These pills let you get quicker emerging erections, harder erections and longer lasting erection. They help you to avoid too early ejaculation
They also enhance the sexual appetite. These effects are achiebed by making the
body able to produce hormones and signal substances more effetcively and at the
Please click here to read more or buy - Prosolution Plus
VigRX Delay Spray - Spray to delay the orgasm to the time you want it to occur, and give you opportunity to make your feelings intense
- This spray will delay the time before an orgasm occurs. During this time your feelings will steadily grow. Then you get an ample orgasm at the time you decide.
Please click here to read more or buy - VigRXdelayspray
Provacyl - Drug to help men over 40 to regain sexual energy and vitality
- This natural drug for men gives a general anti-aging effect on the whole body. It is formulated to give a specific revitalization effect on the sexual organs, sexual abilities and sexual feelings. It is specially formulated for men in an age where the production of hormons decrease.
Please go here to read more about this drug to refill sexual vitality and energy
TestRX - Natural medicine to increase your testosterone production and thereby also increase general virility physical energy and bodily constitution
- Testosterone helps to mainatain the ability of erections, general virility, muscular constitution and a vital energy. Men with a low testosterone level due to age and other causes will especially benefit from the effect of these pills.
Drugs and patches to give bigger erections and enhanced virility
VigRXplus pills to make your erections bigger and more vital
- VigRXplus pills will enlarge your erections and improve the capacity of your penis to get erect and stay erect. The pills also make you more vital to have sex in a broader sense.
MagnaRx - pills to make you erect bigger and more rigid, and endure alonger time
- By using these pills your penis will inflate itself bigger and more rigid, and it will hold that large sturdy state a much longer time, and you will otherwise have the energy to be active in bed the time you wish.
Please click here to see a longer description of MagnaRx or to order
ExtenZe- potency and male lust pills
- Make the erections bigger, harder, more durable and generally intensify the
sexual feelings in your mind and body.
Proenhance - Patches to make your penis more effective - To be fixed onto the skin near the penis. They give you greater ability to achieve erections and the erections will be larger and more durable. The patches have the same effect at the penis and genital area as the enhancement pills, but do not influence other body regions directly. They are the solution for men that only want a genitally focused effect or that allready take other supplements to stimulate the body as a whole.
Please click here to learn more or order - ProEnhance
Kits and devices to enlarge the penis, improve penile shape and help hold erections
Penis pumps and rings to make and maintain erections and for penis development and adjustment
- Penis pumps togeather with a penis ring can be used to make and maintain an erection. By cautious use of a penis pump over some time, you can adjust the shape of your penis and reduce bendings and twists and, you may also make your penis larger.
Penis pumps to make erections and to improve penile anatomy
Penis rings to maintain erections
ProExtender - a mechanical instrument to enlarge and straighten the penis gradually and gently to the size and shape you want
- In this kit there is a treatment tool to gradually make your penis as long as you want, make it more robust, and correct penis shape, for example shape problems caused by Peyronys disease. This device gently pulls on the penis. This makes the penis grow more tissue, so that it gets longer, more robust and somewhat thicker. The effect will also reduce penile irregularities like curvatures and twists.
Oils for men to maximize sexual pleasure and stimulate the erections
Prosolutiongel - for immediate and long lasting solid erections
- A gel to apply on the penile head to make thick and hard erections come immediately and last long. You will feel an extreme arousal and intense pleasurful orgasms.
Please click here to read more or buy - Prosolutiongel
Maxoderm - to amplify your erections and orgasms
- Cream for the penis to get larger erections, longer lasting erections and more
Please click here to read more or buy - Maxiderm
Equipment for sexual play, fun and attraction
Equipment for sex fun, condoms, lubricants and erotic massage products
- Through these links you can find all kind of equipment for sexual stimulation, for erotic massage and protection during sex. You can find: Condoms, dildos and vibrators, lubricants, massage lotions, perfumes, penis pumps, sexy underwear, toys for sexual roleplay, sex DVDs and magazines and much more.
The Erotica Store - to see all the equipment of sex toys, please go here
Penis pumps to make erections and to improve penile anatomy
Penis rings to maintain erections
Condoms of all shapes and sizes
Lubricators for a smooth, soft and senual action
Oils, lotions and tools for sensual massage
Anal and rectal toys and lubricants
Attractive perfumes, body hair removal, head hair growth increase
Nexus Pheromones - fragrant for men to attract women
- Perfume for men that arouses and attracts women, using natural reactions
mediated by pheromones. Get a fragrance that instantly awakens a woman's
positive attention and improves your attraction power.
Please click here to find Nexus Pheromones - fragrant for men excite and get attention from women
An exhibition of erotic fragrants for women and men
- There are a lot of erotic perfumes on the market that will give an sexual attraction on other humans by the content of deepworking pheromones or by the mere sexual scent of the product, or both. This link leads to an exhibition of many of those products.
Please go here to see an exhibition of a lot of erotic fragrants and perfumes for women and men
Treat thin hair and baldness - for men and women
- Advecia is a new all-natural herbal
supplement with ingredients proven to provide hair follicles with essential
nutrients that aid in strengthen the hair follicle and the production of hair
from the follicles. It also contains ingredients to block the DHT, the substance in the male body that hinders hair to grow. It can slow down or stop hair loss and may rewake dormant
Please click here to learn more or buy: Advecia
Stop Grow - Ultra hair away - topical hair
remover for both sexes
- Removes unwanted hair by hindering the growth of hair on areas where it is
applied - for both men and women. Use it on areas where you want a hairfree skin. Removes hair permanantly without waxing -
for both men and women.
Please click here to read more or buy - Stopgrow
Products to give better health and fitness for men and women
Feel and look younger, reverce aging
- A better growth hormone production will help regain skin thickness, muscle
intactness, a jouvenile muscle/fat-ratio and other properties of youth. These products makes your body produce more growth hormone to the right time.
Go here for Genf20 - a drug for general rejuvenation of the bodily, mental and sexual capacities and of body proportions
Go here for Genfx - a drug formulated to rejuvenmate generally body shape, strength. potency and mental acuity
Go here for Hyperggh14z - a drug formulated to restore and add more than ever muscle volume, strength and integrity
A great pharmacy of products to improve sexual life and to combat aging changes
- By clicking at the banner below, you will also find more products to rejuvenate and repair body damage than those presented here. The site has several great products to combat chronic problems and aging changes in the skin, blood circulation, joints, digestion and generally working anti-aging drugs. There are also effective products to help slimming and to develop or revitalize your muscles.
Products for men and women to increase potency and sexual satisfaction. Anti-aging medicines. - please click here
More products to optimize sexual life of women and men
More products to help for specific health problems - digestive, cardiovascular, respiratory, rheumatic, nervous, hemorrhoids, thyroid, poor memory, fatigue, edema and more
About PFE5 ( PFE-5 ) or cGMP
specific phosphodiesterase type 5
This is an enzyme in the phosphodiesterase class. It is found in various tissues, most prominently the corpus cavernosum and the retina.
The phosphodiesterase (PDE) isozymes, found in several tissues including the rod and cone photoreceptor cells of the retina, belong to a large family of cyclic nucleotide PDEs that catalyze cAMP and cGMP hydrolysis.
The interest in PDEs as molecular targets of drug action has grown with the development of isozyme-selective PDE inhibitors that offer potent inhibition of selected isozymes without the side effects attributed to nonselective inhibitors such as theophylline.
A PDE5 inhibitor that is significantly more potent and selective than zaprinast (an early PDE5 inhibitor) and comparable in its PDE inhibitory properties to sildenafil (Viagra, 1998), a drug recently approved for the treatment of male erectile dysfunction.
PDE5 is an enzyme that accepts cGMP and breaks it down. The kinetics of binding [3H]sildenafil and [3H]tadalafil to the catalytic site of PDE5.
Both inhibitors bind with high affinity and specificity, and cGMP binding to the allosteric sites stimulates binding of PDE5 inhibitors at the catalytic site. The kinetics of inhibitor binding and inhibition of catalysis imply the existence of two PDE5 conformers, and results of native gel electrophoresis reveal that PDE5 exists in two apparently distinct conformations, i.e., an extended conformer and a more compact conformer.
PDE5 activity is modulated by a rapidly reversible redox switch. Chemical reduction of PDE5 relieves autoinhibition of enzyme functions; allosteric cGMP-binding activity is increased 10-fold, and catalytic activity is increased ~3-fold. The redox effect on allosteric cGMP-binding occurs in the isolated regulatory domain. A change in the state of reduction of PDE5 or the isolated regulatory domain is associated with an apparent conformational change similar to that caused by phosphorylation.
PDE5 is expressed in human colonic cells and in intestinal tissue and its activity is regulated by intracellular cGMP levels in these cells that increase on GCC activation. This presumably occurs through binding of cGMP to the GAF domains in the N-terminus of PDE5, resulting in allosteric activation of the enzyme.
The mechanism of action of E4021 on both the nonactivated and activated forms of rod PDE6 because both states are relevant to understanding how PDE5-selective inhibitors may alter signal transduction pathways in photoreceptor cells. PDE5-selective inhibitors may show good discrimination of PDE5 from most other PDE isoforms.